NGVL

Publications Contributed To

  1. Donsante A, Vogler C, Muzyczka N, Crawford JM, Barker J, Flotte T, Campbell-Thompson M, Daly T and Sands MS. Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors. Gene Therapy 8:1343-1346, 2001.
  2. Goudy K, Song S, Wasserfall C, Zhang YC, Kapturczak M, Muir A, et al. Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice. Proc Natl Acad Sci U S A 2001;98(24):13913-8.
  3. Song S, Embury J, Laipis PJ, Berns KI, Crawford JM, Flotte TR. Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Ther 2001;8(17):1299-306.
  4. Song S, Scott-Jorgensen M, Wang J, Poirier A, Crawford J, Campbell-Thompson M, Flotte TR. Intramuscular Administration of Recombinant Adeno-Associated Virus 2-Alpha 1-antitrypsin (rAAV-AT) Vectors in a Non-human Primate Model: Safety and Immunologic Aspects. Molecular Therapy 6:329-35, 2002.
  5. Snyder RO and Flotte TR. Production of clinical grade recombinant adneo-associated virus vectors. Current Opinions in Biotechnology 13:418-23, 2002.
  6. Zolotukhin S, Potter M, Zolotukhin I, Sakai Y, Loiler S, Fraites TJ, Chido V, Phillipsberg T, Muzyczka N, Hauswirth W, Flotte TR, Byrne BJ and Snyder RO. Production and purification of serotype 1,2 and 5 recombinant adeno-associated viral vectors. Methods 28(2):158-167, 2002.
  7. Zhang YC, Molano RD, Pileggi A, Powers M, Cross J, Wasserfall C, et al. Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation. Transplantation 2002;74(8):1184-6.
  8. Sautin YY, Jorgensen M, Petersen BE, Saulnier-Blache JS, Crawford JM, Svetlov SI. Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury. J Hematother Stem Cell Res 2002;11(4):643-9.
  9. Zhang YC, Pileggi A, Agarwal A, Molano RD, Powers M, Brusko T, et al. Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes 2003;52(3):708-16.
  10. Goudy, KS, Burkhardt, BR, Wasserfall, C, Song, S, Campbell-Thompson, M, Brusko, T, Powers, MA, Clare-Salzler, MJ, Sobel, ES, Ellis, TM, Flotte, TR, Atkinson, MA. Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type I diabetes in nonobese diabetic mice in a dose-dependent fashion. Journal of Immunology, 2271-2278, 2003.
  11. Shklyaev, S, Aslanidi G, Tennant M, Prima V, Kohlbrenner E, Kroutov V, Sautin Y, Campbell-Thompson M, Crawford J, Shek E, Scarpace P, and Zolotukhin S. Sustained rAAV-Mediated Peripheral Expression of Transgene Adiponectin Offsets the Development of Diet-Induced Obesity in Sprague-Dawley Rats. PNAS 100 (24):14217-14222, 2003.
  12. Poirier A, Campbell-Thompson M, Tang Q, Scott-Jorgensen M, Combee L, Loiler S, Crawford J, Song S, Flotte TR. Toxicology and biodistribution studies of a recombinant adeno-associated virus 2 (rAAV2)-Alpha-1 antitrypsin (AAT) vector. PreClinica 2(1): 43-51, 2004.
  13. Song, S., K. Goudy, M. Campbell-Thompson, C. Wasserfall, M. Scott-Jorgensen, J. Wang, Q. Tang, J. M. Crawford, T. M. Ellis, M. A. Atkinson, and T. R. Flotte. 2004. Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice. Gene Ther 11:181-6.
  14. Song, S., Y. Lu, Y. K. Choi, Y. Han, Q. Tang, G. Zhao, K. I. Berns, and T. R. Flotte. 2004. DNA-dependent PK inhibits adeno-associated virus DNA integration. Proc Natl Acad Sci U S A 101:2112-6
  15. Song S, Witek R, Lu Y, Choi Y-K, Zheng D, Jorgensen MS, Li C, Flotte TR and Petersen BP. Ex vivo transduced liver stem cells as a platform for gene therapy. Hepatology 40(4):918-924, 2004.
  16. Wei F-S, Song S, Zhao G, Lu Y, Li C-W, Wei J-F, Flotte TR. Stable transduction of murine embryonic stem (ES) cells with recombinant adeno-associated virus serotype 2 (rAAV2) vectors. Preclinica 2(4):262-266, 2004.
  17. Zhang, C. , M. Powers, C. Wasserfall, T. Brusko, S. Song, T. Flotte, R. Snyder, M. Potter, M. Scott-Jorgensen, M. Campbell-Thompson, J. M. Crawford, HS Nick, A Agarwal, .T. M. Ellis, M.A. Atkinson. Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity. Gene Therapy, 11(3):233-40, 2004.
  18. Lu, Y., H. Dang, B. Middleton, Z. Zhang, l. Washburn, M. Campbell-Thompson, M. A. Atkinson, S. S. Gambhir, J. Tian, and D. L. Kaufman. Bioluminescent monitoring of islet graft survival after transplantation. Molecular Therapy, 9 (3): 428-436, 2004.
  19. Matthias H. Kapturczak , Clive Wasserfall, Todd Brusko, Martha Campbell-Thompson, Tamir M. Ellis, Mark A. Atkinson, and Anupam Agarwal. Heme oxygenase-1 modulates ea rly inflammatory responses: Evidence from the heme oxygenase-1 deficient mouse. Am J Pathology, in press, 2004.

Poster Presentations

  • Poirier A, Combee L, Martino A, Conlon T, and Flotte TR. Toxicology and biodistribution of AAV-AAT vectors. Presented at the American Society of Gene Therapy meeting, Minneapolis, MN, June 2-6, 2004.
  • Poirier A, Combee L and Flotte TR. Toxicology and biodistribution of AAV-AAT vectors. Presented at the American College of Toxicology meeting, November 2-5, 2004, Washington D.C.
  • Poirier AE, Conlon TJ, Combee LA, Erger KE, Flotte TR. Presented at the American Society of Gene Therapy conference, St. Louis, MO, June 1-5, 2005.

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